![]() Your ISP and other third-parties will no longer be able to see and record your online activities with your VPN connection active. By encrypting your internet traffic through a VPN, you achieve a higher level of privacy and security online. Privacy concerns – As we have covered before, there is a growing concern about online surveillance, privacy, and data security.(A VPN gets around ISP throttling and encrypts all traffic, making your activities invisible to your ISP.) This is done for various reasons, but it ultimately results in a headache and streaming problems. ISP throttling – This growing trend is when your ISP ( Internet Service Provider) throttles or limits your connection speed.This is called geo-blocking and a VPN allows you to break through by changing your IP address and making you appear to be in the country you want. If your IP address is not in this location/country, then you will be blocked. Content restrictions – Content is often restricted to certain geographic locations.If you are not using a VPN with Firestick, you will likely experience these problems: Simply put, a VPN is essential for Firestick users to get unlimited access to the widest selection of content, without getting restricted by your ISP. If you want to maximize your Firestick streaming experience, then you will need a good VPN service. Before we really dive into this topic, the table below highlights the best VPNs for Firestick based on the latest test results: We have tested all of the most popular VPNs to see how they work with Firestick. Another problem we have identified with many popular VPNs is that they are too slow for streaming, which results in playback issues and interruptions.Īt the end of the day, you need a VPN that works well with Firestick and Fire TV - and not just any VPN will work. In fact, many VPNs have no dedicated app for Firestick and Fire TV. ![]() ![]() Many VPN’s advertise compatibility with Firestick - but they don’t actually work well. ![]() Using the best VPN for Firestick gives you the best streaming experience possible, with unlimited access to all content. The Firestick (or Fire TV Stick) and Fire TV models remain the best option for streaming by giving you instant access to a huge library of content and numerous streaming services, while also being compatible with many different devices. In this new and updated guide we’ll examine the best VPNs for Firestick and Fire TV, as well as easy setup instructions and Firestick VPN FAQs (Frequently Asked Questions).Īs online streaming continues to grow in popularity, more people than ever are using Firestick and Fire TV to stream their favorite media. ![]()
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![]() Through Manpower, local area companies can also easily manage their entire Human Resource process, from employee recruitment and onboarding to compliant payroll setup and off-boarding.Īs always, we're eagerly looking forward to facilitate your career goals or your company's unique needs. This page uses military occupational specialty codes from the ONET 25.0 Database by the U.S. If you're in the job market, searching for a career or something to do part time, we welcome you to search the jobs that we have available.Īdditionally, Manpower provides companies with a competitive advantage through a tailored customer experience that is aimed at delivering an employment and staffing solution that is unique to your organization. Leveraging its game changing JobStack staffing app and presence in more than 600 markets throughout North America, PeopleReady served approximately 83,000 businesses and put approximately 226,000 people to work in 2022. ![]() ![]() Providing complete staffing and recruitment solutions, sourcing and supplying. ManpowerGroup serves both large and small organizations across all industry sectors through our brands and offerings: Manpower, Experis and Talent Solutions. Feel free to review all the career resources that we have available or reach out to us in any way you're comfortable. Are you searching for temporary labor near me PeopleReady can provide 24/7 access to the workers you need. Aarvi Encon is a leading manpower supply and outsourcing company in India. We pride ourselves on efficient and effective hiring practices, not only for our clients, but our own employees too. Our team members thrive on success, and for us, success means when you win, we win. Where do I begin? Who do I call? Where do I go? What do I qualify for? Where would I get a resume?Īt Manpower of the Palm Beaches and the Treasure Coast, we strive to create a unique approach that is aimed at setting us apart from the rest which has made us the staffing and employment agency of choice for many exclusive clients in your area. Since 1961, Manpower has been a leader in temporary and permanent staffing in Maine. ![]() As a staffing and employment agency, we understand that job searching can be a little intimidating and often times, be a tough task. the specialized skills of ( Table 6-10 ) Staffing of Environment Preservation Department ( Unit : No of persons ) Total Manpower Needs Drafted Manpower. ![]() ![]() In both, you can freely create Channel Clusters from two or more channels and process them independently, plus you can open, save and edit multi-channel files just as you can with stereo or mono files you can also select specific channels to open in external audio editors. Support for multi-channel interleaved files has been expanded, with WaveLab Pro supporting up to 22.2-channel surround layouts of WAV files, and WaveLab Elements supporting up to 5.1 surround. Several adjustable parameters allow you to fine-tune the ducking behavior. The new auto-ducking feature in the Audio Montage window allows you to set the voice track (or any other track) as a modulator that will automatically duck another track. In podcasts and other productions featuring spoken words, it’s often necessary to duck the music at times to let the voices come through. WaveLab 11 also includes all the features of Steinberg’s dedicated podcast production software WaveLab Cast. WaveLab 11 adds a powerful feature to speed up and simplify your workflow when creating and editing podcasts: the ability to upload content directly to directories like Spreaker, Podbean, Soundcloud, Buzzsprout and Castos. Once you’ve finished editing the audio, you can render the video in its original format. You can now replace part or all of a video’s audio track from within WaveLab, without affecting the video quality. ![]() The program also can suspend processing on plug-ins when they’re idle, saving CPU resources. If you’ve got a session with many tracks, clips and plug-ins, you’ll notice a speed boost if you’re working on a fast computer. WaveLab 11 supports multicore processors for Audio Montages, making its performance even faster. The Enhance section offers four more effects: Voice Exciter with Amount and Clarity controls Reverb with Size and Mix controls EQ with Low, Mid and High-frequency knobs, as well as a Low Cut filter and Maximize with an Optimize control. The DeHummer offers options for removing 50 or 60 Hz hum, while the DeEsser has a Character Control for differentiating between male and female voices. ![]() All have a Reduction knob for controlling the amount of processing, along with a Listen knob for monitoring the part of the signal removed by the effect. The Clean section features three effects: DeHummer, DeNoiser and DeEsser. Clicking on the Track Effects shortcut brings up two distinct sections: Clean and Enhance, each with on/off buttons and one-knob controls. The new Clean and Enhance windows in the Track Inspector provide convenient real-time processing of individual tracks. Clean and Enhance Track Inspector Windows Space doesn’t allow covering all the new capabilities, but let’s take a look at some of the highlights, starting with those common to both the Elements and Pro versions. These additions beef up WaveLab’s already prodigious toolset for mastering, audio for video, podcast production and more. ![]() With the release of WaveLab 11, Steinberg added over 40 new features and enhancements to its flagship audio editor. ![]() ![]() You can employ text, images, data, and even video to communicate the story of the design idea to the client.Īlthough Aurora does not have all the features necessary to create extensive and powerful 3D models, it gets the job done effectively. This software is easy to use and it offers a variety of styling and presentation boards. Aurora 3D SoftwareĪnother effective 3D presentation software is Aurora 3D. ![]() The MagikTour interactive 3D design software is perfect for all projects, whether you have a small or large interior design business. You can send the link to the client who can evaluate and approve or share their concerns to make an informed decision. The software allows you to share your ideas along with the design process through a link. It is a handy tool, especially if you don’t want to waste money on transportation. This software is effective in creating 360-degree floor plans and implement design ideas as per the client’s requirement. This simple software created by Foyr enables you, as interior designers and architects, to connect with your clients directly. Our first and most favorite choice is MagikTour. While AutoCAD and SketchUp are some of the top choices, the following architectural software provides additional means to create attractive presentation boards that can elevate the output of your interior design services. The pricing and styling may differ from one software to another, based on the templates you choose. There are several interactive 3D presentation software that facilitates multiple presentation techniques for schematic visualization of your design plan. See also – Best Interior Design Software 10 Best Interactive 3D Architectural Presentation Software It helps them make up their mind before they give their approval so that there is a minimum to no scope for errors upon completion of the interior design services. With careful brainstorming, you and your client can arrive at a mutual understanding before you create final presentation boards for your interior design project.ĭecorators can also use interactive 3D presentations so the client can hover over the plans and inspect the view from every angle as if they are present right in the room. This is especially useful for new clients as they can share their own design plans with you. An interactive 3D presentation enables you to show the client exactly what you have in mind with accurate visualization. ![]() With 3D modeling software, you can create a virtual rendering of the home design. without a visual aid.Īlthough Photoshop or PowerPoint presentations can help, the real challenge is visualizing the space from all angles. It is a little difficult to explain the concepts of scales, floor plans, room design, etc. Interior designers and architects have an obligation to their clients to deliver the property designs to meet their expectations. ![]() Image credits: What is an Interactive 3D Presentation? While all the mood boards and floor plans are easily accessible and displayed on a 2D surface, 3D models take the effects of the architectural visualization to a whole new level. However, the best means for interior design presentation are 3D models. You can also use sample boards so they can check out the templates and color schemes you wish to implement. For new clients, using swatches and templates is a great way to introduce them to your design ideas. Interior designers can use various inspiration boards and design concepts to bring the client’s requirements to life. This important art form is a means for introducing creativity in any given room design and turn it into the homeowner’s dream house. ![]() Interior Design is an exciting field of study. Home » Architecture Concepts » 3D Design, Modeling & Rendering » 10 Best Interactive 3D Presentation Software for Designers Interior Design 3D Presentation ![]() ![]() ![]() ![]() Her father is Japanese, while her mother is Italian-American. Japanese top model Hikari Mori on her beauty philosophy, red light therapy and edible skincare The 31-year-old Japanese model was recently named Shiseido’s global ambassador. As of now, Hikari Mitsushima’s estimated net worth stands at around 5 million. With an exceptional talent and skillset, Hikari Mitsushima has established a successful career over the years, earning widespread recognition and acclaim. Izumi Mori ( 森 泉, Mori Izumi, born October 18, 1982, in Minato, Tokyo, Japan) is a Japanese model and tarento represented by Oscar Promotion. Hikari Mitsushima is a well-known Film Actress who was born on Novemin Japan. Pamela Mori (Pamela Ann Harris) (mother).We caught up with Hikari to learn more about her current skincare routine (hint: it involves the Eudermine Activating Essence), beauty philosophy and the trends that she’s excited to try. She has been represented by The Society Management in New York and Bon Image Corp. Official profile of Japanese fashion model Hikari Mori born in Tokyo, Japan, including biography, photos, FMDcard, sed card, lookbook, portfolio, videos, agencies. Viviendo el infierno todos los días, Lavender cree que su situación no puede empeorar hasta que Lia le presenta nuevos amigos para que juegue con ellos. Two of her granddaughters, Hikari Mori and Izumi Mori, are fashion models. Secuestrada y llevada a una mazmorra secreta, la pobre chica se ve obligada a soportar una tortura y humillación interminables para divertir a la sádica princesa. We introduce how to incorporate the cleanse and the impressions. People call me different names, so sometimes I just say Hiki, what my mom calls me. So, I write my name ‘star’ but I read my name ‘Hikari’it’s kind of hard to figure out. ![]() (Check out our honest review of the Shiseido Eudermine Activating Essence here.) Moris husband of almost 50 years, Ken Mori, died in 1996, and she is survived by two sons. This is the interview page of Izumi Mori and Hikari Mori of Juice Cleanse of Sunshine Juice. Using Japanese characters, you can’t read it ‘Hikari,’ you read it ‘Hoshi,’ which means star. With 126 years of evolution, it’s a product that has stood the test of time and made better with every iteration. The current form of Eudermine was launched in 1997 to mark the centenary of its creation. The essence lotion gained popularity as ‘Shiseido’s Red Water’ and the formulation has been continually improved over the years. It has a history of being used in Japanese beauty rituals and was popular with geishas who used it to protect their skin under heavy makeup. By keeping the skin’s radiance and clarity, I feel like I’m able to become more positive from within,” she adds.Įudermine was Shiseido’s first cosmetic product, launched in 1897. I love the naturally sweet scent, texture and the sensation of it that brings out skin’s inherent moisture. More at IMDbPro Contact info Agent info Resume Add to list Known for Aoi sora shiroi kumo Actress 2012 VS Arashi 8. “I like the fact that Shiseido Eudermine Activating Essence focuses on ingredients coming from nature’s blessings such as kefir and Japanese rice. Hikari Mori is known for Aoi sora shiroi kumo (2012), VS Arashi (2008) and The Final Table (2018). ![]() ![]() Even if you lose that bet, you'll still receive rewards if you win. If you play online, place a wager to compete against someone else. Making a hole in the ball gives victory a sense of accomplishment. This makes the game more interesting and exciting to play. Playing the game is like playing a regular mini golf game, but it's 3-dimensional instead of 2-dimensional. The game is well-designed with an easy to use interface and a competitive multiplayer mode. There are about 200 different levels in the game Mini Golf 3D City Stars. You can overcome these problems by searching for solutions in the number of turns displayed in the upper portion of the screen. You must face challenges like barriers and obstacles that move across the screen, plus confusing mazes and bottlenecks. Aim to clear the limited number of hits you're given. This makes it easier to complete than similar games such as Golf Clash. The game has several challenging levels that you can play through with ease. You need to get the ball through the end of the lane and into the hole ahead of your opponent. At the start of the game, a ball rolls down a lane. You'll golf through many amazing holes before attempting to hit the target with accuracy. The game is part of the Arcade genre it features a fun sport known as minigolf. Test your skills on the 3D mini golf course in Mini Golf 3D City Stars. Like "Golf Clash," you can access many great features and pick a cool flag for your favorite sport. You can also pick a Cheetah skinball, Zebras or Giraffe for your animal ball. You can choose from different country flags, and if you're a nature lover you can pick from the Lightning, Northern Lights, Milky Way and other cool shadow upgrades. You can choose from a soccer ball, baseball, tennis ball or basketball. These can be used to purchase new equipment and upgrades. In Mini Golf 3D City Stars, players earn diamonds and coins after each round of play. The better you show off your skills on the course, the higher your chances of winning. A real-time multiplayer game involving single-player mini golf and PvP. As you do this, you need to use your power button effectively and overcome difficult obstacles like fun challenges. You also have to overcome various challenging obstacles such as animated objects like loops and jump stars. You need to think creatively, use the power-button correctly and pick the right angle for your arrows when putting the ball in the hole. The game is easy to play, but takes some time to get used to. Your goal in this golfing simulator is to help the ball travel the direction you need it to go. The game features 245 putt-putt paths, each with a unique set of obstacles. Many users get a kick out of the free game's 3D effects and additional content updates on a regular basis. Nonetheless, the space golf sim has plenty to offer. However, most of them are obsolete quickly and if they don't update regularly, many codes you receive that don't work anymore.When mentioning the contents of the game, Mini Golf 3D City Stars doesn't go much farther than its rival conflicts in Aztec El Dorado World. In order to make the best out of the game, many authors tried hard to find out a list of golf clash cheat codes, to get coins and gems. The motive behind every action in this game is to get more coins and gems. All the leaders in this game are just manipulating the glitches of the game to their favour.Įverything runs around them (coins) and for them. Without them, searching any golf clash hack or free gems is a waste of time. It will enhance your creativity in the game and open new dimensions and perceptions of how to play the game. If you want golf clash free gems, then first read the tricks mentioned in the link below. ![]() Its just the art of making coins and investing them again and again to get more coins and gems and vice versa. ![]() This game is not any rocket-science or containing any special skill to master. Apply them cautiously to get more free gems, you will have a good experience in golf clash. ![]() Apart from this the techniques mentioned above are the best way to understand golf clash cheats. There are some groups on reddit also that can help you in exchange of gems and coins. Rather than being fooled by other mods or fake tools, resort to this real-working golf clash hack above to advance quickly with lightning speed. This keeps players hooked on gathering resources and trying to win as many Golf Clash matches as they can. Perhaps the most addictive feature of this game is the Golf Clash upgrades, items and constant hunger for seeking better challenges. ![]() Here is a picture of what the 1st place winner of the ‘Pro Tourney’ got as a result of coming 1st place They are really fantastic since they give players opportunities to get some great rewards. There are always Golf Clash tournaments coming up multiple times around the year. ![]() ![]() In a later scene in the level, Jackie is knocked on his back and his legs flail up in front of the camera before he lands. Shortly after, the situation becomes dire enough that Jackie must unleash the Darkness to survive, and the Darkness' Healing Factor completely restores his leg, though he is missing his right shoe with the pants on that side still all torn up. Blooper: During the opening stage of The Darkness II, Jackie's right leg gets torn up quite badly in a mob ambush, and one of his men must drag him away while Jackie fends of attackers with a pistol.Banned in Singapore: The first game was originally banned from the country for excessive violence and blasphemy, but in 2008 after Singapore introduced a proper video game ratings classification system it was re-classified to M18 and released.B-Team Sequel: The second game was developed by Digital Extremes, of Warframe fame.The Wiki Rule: The Image Comics Database, the Top Cow Universe Wiki and The Darkness Wiki.In following the blueprint of the original, DOD2 doesn't qualify as an essential classic of the genre (it's no The Untold Story or Red to Kill), but the exploitative sex, nudity, and violence should keep most fans of Cat III nastiness happy for the duration. With Ken gone, Sau turns to Kun for help in evening the score, but when he leaves (after bonking Sau one last time, of course), it is up to her to take revenge, which she does in a variety of nasty ways, including the use of a board of nails, a bear trap, a big knife and a sharp bamboo pole. Unfortunately, Ken just happens to catch her in the act, and goes to find Hung looking for revenge, which results in him being roughed up and chucked in front of a moving truck. There's only one thing for the lady to do: in the film's most nauseating moment, Sau takes a coat hanger and performs a home abortion in the shower. Ken finally arrives with the money and leaves with his wife, who goes to the doctor to find that she is not only pregnant but also infected with syphilis. While they wait for him to find the money, the blackmailers take Sau to their home, where they rape her, to the amusement of Hung's equally wicked wife. With proof of Sau's infidelity, Hung demands a large sum of cash from Ken in return for the photos. Obviously Kun agrees, especially since Ken is willing to pay handsomely for the task! Having thoroughly enjoyed himself, Kun decides he wants more of the lovely (and accommodating) Sau, but this time they are photographed in the act by Hung and his son. Kun quickly becomes good friends with the couple, but clearly has an eye for the lovely Sau, which is why Ken, impotent as the result of a war wound, asks him to perform a favour: impregnate his wife so that he can have a son. Friendly local Kun (Dick Lau) comes to the couple's rescue and offers them a place to stay while their car is fixed. Sau and her husband Ken (Ben Ng) are driving through the countryside when they swerve off the road to avoid hitting some people instead, they almost run over thug Hung (Ka-Kui Ho), who demands compensation with menace. It all starts as suspect Sau (Yim Lai Cheng) recounts her story to the police chief. ![]() ![]() ![]() Thirty minutes or so of such silliness and we're finally headed for the more extreme content that Cat III films are renowned for: sexual violence, rape, murder, and more. I can't say I found any of this particularly funny, but each to their own. The film opens with bumbling cops investigating the killing of a family, which results in such hilarity as the sexual molestation of a (presumed dead) woman, group masturbation, and the eating of a semen covered mango by a big-chested female cop. It's been thirteen years since my IMDb review for Daughter of Darkness, so my memory is a little hazy, but this sequel, which was made the year after the original, seems to follow the same formula: lots of typically wacky bad-taste HK comedy with a little gratuitous sex/nudity, followed by the nasty stuff. ![]() ![]() ![]() ![]() You can click on the title to jump to that section. Whether or not you speak Spanish itself, these lists will help you find the best music for every occasion– for you, your family, or your Spanish classroom!įirst, here’s an index to get you to the right section. I’ve been creating song lists for a while and have many more to go, but this page is a great beginner’s guide. You can find songs in Spanish for every mood and age. Latin music is a complex phenomenon that reflects the complex history of Latin America, a mixed region whose social environment has forged some of the most beautiful sounds in the world. Music in Spanish is an entire world, packed with amazing rhythms, poetry, and dance. ![]() Mi persona favorita – Alejandro Sanz, Camila Cabelloħ.Inside: A guide to Spanish songs by themes and learning levels. Es que yo sin ti, y tú sin mí, dime quién puede ser feliz, esto no me gusta, esto no me gusta…” Still looking for more Spanish love songs, both recent hits and classics?ġ. “Yo sé que él te parece mejor, pero yo estoy en tu corazón, y por eso pido perdón. The official music video made it popular as well, as the singer is watching his first love get married and telling her to forgive him and return to be together instead. “El Perdón” was a huge success in 2015, from Puerto Rican reggaeton artist Nicky Jam and Colombian singer Enrique Iglesias. El perdón – Nicky Jam and Enrique Iglesias “Solo tú Solo tú que conoces mi forma de sentir Mi forma de reír Y hasta mi forma de llorar…”ģ0. It was released in 2000, from Mexican singer Pedro Fernández. Remember the best of romantic Mexican pop ballads with this gorgeous song about the feeling of love and being known by someone. “Pasito a pasito, suave, suavecito Nos vamos pegando, poquito a poquito Y es que esa belleza es un rompecabezas Pero, pa’ montarlo, aquí tengo la pieza…” It was a massive commercial success, breaking several records for streaming and sales, and became the first Spanish-language song to reach over 4 billion views on YouTube. This sensual Reggaeton was released in January 2017 and quickly became a global hit, reaching #1 on the charts in over 50 countries and holding the record for most weeks at #1 on Billboard’s Hot Latin Songs. “El campo real El manantial Yo te daré amor, cuando me digas si Cuando me digas sí…” This bolero will bring back all the feels of Latin love music. Cuando me digas sí – Richie Ray, Bobby Cruz, Miki Vimari “ Todo amor que yo espere de la vida, Lo he encontrado solo en ti…”Ģ7. This is a classic of Argentine rock and I love the emotional duet here. “ Bésame Bésame mucho Como si fuera esta noche La última vez…” Andrea Bocelli performs the the song live in the video. El perdón – Nicky Jam and Enrique IglesiasĬan it get any more classic than Bésame mucho? This is an iconic Spanish love song that belongs on every list of romantic songs. Mi historia entre tus dedos – Gianluca Grignani 26. Por el amor de una mujer – Julio Iglesias 19. Contigo aprendí – Alejandro Fernandez 16. If I missed one of your favorites, let me know in the comments below!ġ. Let’s take a tour of our top picks, and don’t forget you can access this list on Spotify too. Related: The Tops Spanish Songs of All Time THE BEST SPANISH LOVE SONGS And of course, music in Spanish can make your perfect background for Valentine’s Day, or whatever love-is-in-the-air sort of time it may be. No wonder Latin music and poetry are famous. It’s no secret that Spanish is a romantic language– and no, I don’t mean that it’s one of the Romance Languages! Rocket Languages says:Īs one of the world’s most widely spoken languages, Spanish tops off our list as one of the world’s most romantic languages because of its passionate, sensual sound. Inside: The best Spanish love songs: A Latin Playlist. ![]() ![]() It’s important to determine whether the discoloration also appears when the cold water is running. Tinted hot water, either red or dirty yellow, coming from any faucet could mean rust.If cleaning the tank doesn’t solve the problem, it may be time to call a plumber. It could be metal that’s absorbed in the water, or it could be bacteria collecting inside the tank. If there is a weird smell or taste to the hot water, then something may be contaminating the water tank. The sediment builds, hardens, and eventually forms a thick crust that can cause the water heater to creak and bang when in use. While manufacturers recommend annual flushing of a tank-style water heater-and it’s a requirement for keeping a warranty in effect-few people actually follow that suggestion, so calcium buildup from hard water collects in the bottom of the tank. A banging or rumbling noise often occurs near the end of a water heater’s lifespan.Even though all appliances have an average lifespan that’s based on typical use, it’s a good idea to start shopping for a replacement if you notice any of the following signs. More than just maintaining your water heater according to the manufacturer’s instructions, it’s important to regularly check the performance of a hot water heater to make sure it’s performing optimally. Electric Water Heaters Signs Your Water Heater Might Be on Its Last Legs RELATED: Choosing a New Appliance: Gas vs. This rule of thumb applies to most hot water heater manufacturers, but you can confirm this on the company’s website if you have any doubts. A serial number that leads with “A10,” for example, was manufactured in January 2010. ![]() Typically, the letter stands for the month-“A” for January, “B” for February, and so on, through “L” for December-and the next two numbers indicate the year it was made. Your existing water heater’s serial number holds the clue to its age.Įven if you can’t track down the documentation for your current appliance, you can examine the serial number, which consists of a letter followed by a series of numbers, located on the upper portion of the water heater to determine when it was manufactured. RELATED: Best Water Heaters for Homeowners ![]() Once corrosion starts inside the tank, the water heater has entered into its final stage of life. When the rod has corroded to such an extent that it can no longer do its job, those particles settle at the bottom of the water tank, where they may eventually destroy the lining. Inside the tank, an anode rod protects the interior lining by attracting all corrosive particles to itself through a process called electrolysis. A traditional tank-type water heater lasts an average of 8 to 12 years. While a water heater may be able to outlast average estimates, there are expectations for how long a water heater will last based on type. In addition to its age and whether it receives regular maintenance, the quality of the water and the levels of regular usage also affect the water heater lifespan. There are many factors that affect a water hexater’s life expectancy. If you’re wondering, “How long do water heaters last?” keep reading to find out the signs of aging and what to consider when planning to update an old water heater. ![]() ![]() ![]() “T-DM1 really works in this population,” said Louis Weiner, M.D., of the Georgetown Lombardi Comprehensive Cancer Center during the plenary session. Blackwell noted, and more women in the control group had to have their dose reduced because of side effects. The thrombocytopenia was effectively managed with dose reductions, Dr. However, with additional follow up time the published results revealed a statistically significant increase in overall survival for women treated with T-DM1: median survival was 30.9 months in those who received T-DM1, compared with 25.1 months in those who received capecitabine and lapatinib.Īlthough more women taking T-DM1 had a potentially dangerous drop in platelet levels (thrombocytopenia), other side effects such as vomiting, diarrhea, and hand-foot syndrome were much more likely in women in the control group. In the initial analysis presented at ASCO, overall survival was similar in the two treatment groups. The results were based on two interim analyses of the trial’s data. The median progression-free survival in women treated with T-DM1 was 9.6 months, compared with 6.4 months in women treated with capecitabine and lapatinib. ![]() T-DM1 is an antibody-drug conjugate composed of the monoclonal antibody trastuzumab, which targets the HER2 receptor on breast cancer cells, chemically linked to the chemotherapy drug DM1. The drug’s manufacturer, Genentech, stated it will seek approval from the Food and Drug Administration this year for use of T-DM1 in women with metastatic breast cancer. “T-DM1 should offer an important therapeutic option in the treatment of HER2-positive breast cancer,” said the study’s lead investigator, Kimberly Blackwell, M.D., of the Duke Cancer Institute at Duke University. 1, 2012, in the New England Journal of Medicine.) (The results were subsequently published online Oct. With one exception, T-DM1 also had far fewer serious side effects than the capecitabine-lapatinib combination, the trial’s leaders reported at the 2012 American Society of Clinical Oncology (ASCO) annual meeting. Women who received the investigational drug trastuzumab emtansine (T-DM1) lived more than 3 months longer without their tumors progressing than women who received the chemotherapy drug capecitabine (Xeloda®) and the targeted drug lapatinib (Tykerb®). Results from an international clinical trial suggest that women with metastatic HER2-positive breast cancer that is no longer responding to the targeted therapy trastuzumab (Herceptin®) may soon have a new treatment option. ![]() |